Publications by authors named "C Dehghani"
Time-lapsed in vivo corneal confocal microscopy (IVCCM) has shown that corneal dendritic cells (DCs) migrate at approximately 1 µm/min in healthy humans. We have undertaken IVCCM of the whorl region to compare the density of rounded DCs, and DCs with (wDCs) and without (woDCs) dendrites and dynamics; trajectory (length travelled/time), displacement (distance from origin to endpoint/time) speeds and persistence ratio (displacement/trajectory) of woDCs in subjects with type 1 diabetes (T1D) (n = 20) and healthy controls (n = 10). Only the wDC density was higher (p = 0.
View Article and Find Full Text PDFClinical Relevance: Knowledge of the typical eye health profile of patients experiencing social or economic disadvantage is useful for health care modelling.
Background: The aim of this work is to profile the ocular health and sociodemographic characteristics of Australian College of Optometry service users of all ages and to explore the relationships between key sociodemographic characteristics and eye health.
Methods: For 3093 eye examinations, best-corrected distance visual acuity and mean spherical equivalent refractive error were tested non-parametrically by clinic category, remoteness area, number of co-morbidities, gender and indigenous status, also correlated against age and socioeconomic advantage/disadvantage.
Objective: Corneal nerve fiber length (CNFL) has been shown in research studies to identify diabetic peripheral neuropathy (DPN). In this longitudinal diagnostic study, we assessed the ability of CNFL to predict the development of DPN.
Research Design And Methods: From a multinational cohort of 998 participants with type 1 and type 2 diabetes, we studied the subset of 261 participants who were free of DPN at baseline and completed at least 4 years of follow-up for incident DPN.
Article Synopsis
- The study aims to identify non-invasive imaging biomarkers for neurodegenerative disorders by examining corneal sensory nerve and dendritic cell characteristics using confocal microscopy in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD).
- Fifteen participants were analyzed, revealing that those with MCI exhibited significantly altered dendritic cell shape and area compared to cognitively normal controls, though changes in corneal nerve architecture were not statistically significant.
- The findings suggest that corneal dendritic cells could serve as potential biomarkers for early detection of neurodegenerative conditions, highlighting the need for further research in this area.