A Comprehensive SWOT and TOWS analysis of transfusion medicine: Indian Perspective.

Background And Objective: SWOT and TOWS analysis is a strategic planning tool for identifying internal and external factors influencing a field. It helps to identify areas for improvement and growth by maximizing strengths and opportunities while minimizing weaknesses and threats. Transfusion medicine specialists can better understand the field's current status and plan potential growth using SWOT and TWOS strategic tools.

Association of exosomal miR-96-5p and miR-146a-5p with the disease severity in dengue virus infection.

Exosomes are small extracellular vesicles secreted by cells and have a major role in cell-to-cell signaling. As dengue infection progresses from a mild to a severe form of infection, the exosome's microRNA (miRNA) composition might change, which may contribute to pathogenesis. In this study, a comprehensive analysis of serum exosomal miRNAs was performed and their involvement in dengue virus-induced disease progression in an Indian cohort was assessed.

Sustainable Production of Pigments from Cyanobacteria.

Pigments are intensely coloured compounds used in many industries to colour other materials. The demand for naturally synthesised pigments is increasing and their production can be incorporated into circular bioeconomy approaches. Natural pigments are produced by bacteria, cyanobacteria, microalgae, macroalgae, plants and animals.

RG203KR Mutations in SARS-CoV-2 Nucleocapsid: Assessing the Impact Using a Virus-Like Particle Model System.

The emergence and evolution of SARS-CoV-2 is characterized by the occurrence of diverse sets of mutations that affect virus characteristics, including transmissibility and antigenicity. Recent studies have focused mostly on spike protein mutations; however, SARS-CoV-2 variants of interest (VoI) or concern (VoC) contain significant mutations in the nucleocapsid protein as well. To study the relevance of mutations at the virion level, recombinant baculovirus expression system-based virus-like particles (VLPs) were generated for the prototype Wuhan sequence along with spike protein mutants like D614G and G1124V and the significant RG203KR mutation in nucleocapsid.

ADAMTS13 factor deficiency in severe COVID-19 may not be immune mediated - report from a pilot study.

Background: The assessment of ADAMTS13 factor activity and inhibitor levels was conducted in severe COVID-19 patients as an observational study.

Results: A total of 14 patients were included and the average ADAMTS13 activity level at the time of admission was 28.54±30.