Publications by authors named "C De Wit"

Article Synopsis
  • Misophonia is a sound sensitivity disorder often starting in childhood, and there are currently no effective questionnaires to assess its severity in youth.
  • This study introduced and validated two new questionnaires: the Misophonia Screening List-Child and Youth for screening, and the Amsterdam Misophonia Scale-Youth (AMISOS-Y) for measuring severity.
  • The questionnaires were tested on a diverse sample and showed strong psychometric properties (α = 0.95-0.96), but future studies are needed for broader validation in community and clinical settings.
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Children are exposed to endocrine disrupting chemicals (EDCs) through inhalation and ingestion, as well as through dermal contact in their everyday indoor environments. The dermal loadings of EDCs may contribute significantly to children's total EDC exposure due to dermal absorption as well as hand-to-mouth behaviors. The aim of this study was to measure potential EDCs, specifically halogenated flame retardants (HFRs) and organophosphate esters (OPEs), on children's hands during preschool attendance and to assess possible determinants of exposure in preschool indoor environments in Sweden.

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The idea of guidance toward a target is central to axon pathfinding and brain wiring in general. In this work, we show how several thousand axonal growth cones self-pattern without target-dependent guidance during neural superposition wiring in . Ablation of all target lamina neurons or loss of target adhesion prevents the stabilization but not the development of the pattern.

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Article Synopsis
  • Actin binding proteins are essential for regulating the actin cytoskeleton, impacting various cellular processes like movement and adhesion.
  • The Ena/VASP family, discovered over 30 years ago, plays a critical role in enhancing actin filament assembly and linking molecular signaling pathways to these processes.
  • This review focuses on the distinct and overlapping functions of Ena/VASP proteins specifically in cardiovascular cells, exploring their physiological roles and molecular mechanisms.
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This study analysed settled dust samples in Sweden to assess children's combined exposure to 39 organohalogenated flame retardants (HFRs) and 11 organophosphate esters (OPEs) from homes and preschools. >94 % of the targeted compounds were present in dust, indicating widespread use of HFRs and OPEs in Swedish homes and preschools. Dust ingestion was the primary exposure pathway for most analytes, except BDE-209 and DBDPE, where dermal contact was predominant.

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