Publications by authors named "C De J Labuschagne"
Article Synopsis
- The Global Mercury Observation System (GMOS) started as a five-year initiative to monitor atmospheric mercury and evolved into a major program supporting global mercury observation efforts under the Minamata Convention.
- The network consists of 28 ground-based monitoring stations that provide comprehensive data on mercury levels across various latitudes, from the Arctic to the Antarctic.
- Analysis of mercury data from 2011 to 2020 revealed a significant north-south gradient in mercury concentrations, with notable seasonal variations and decreasing trends in certain remote areas.
The unintended environmental exposure of vultures to diclofenac has resulted in the deaths of millions of old-world vultures on the Asian subcontinent. While toxicity has been since associated with a long half-life of elimination and zero order metabolism, the actual constraint in biotransformation is yet to be clarified. For this study we evaluated if the evident zero order metabolism could be due to defects in the CYP2C9/2C19 enzyme system.
View Article and Find Full Text PDFPrevious studies have revealed a role for proline metabolism in supporting cancer development and metastasis. In this study, we show that many cancer cells respond to loss of attachment by accumulating and secreting proline. Detached cells display reduced proliferation accompanied by a general decrease in overall protein production and de novo amino acid synthesis compared to attached cells.
View Article and Find Full Text PDFArticle Synopsis
- Mitochondrial 10-formyltetrahydrofolate (10-formyl-THF) is broken down by the enzyme ALDH1L2 in mitochondria to produce NADPH, which helps combat oxidative stress, and contributes to nucleotide synthesis and mitochondrial protein production.
- Reducing expression of ALDH1L2 in breast cancer cells leads to increased reactive oxygen species (ROS), along with higher levels of formate and fMet—both of which are linked to enhanced cancer cell mobility through formyl-peptide receptor (FPR) signaling.
- In different tumor models, higher levels of ALDH1L2 help limit the accumulation of formate and fMet, thereby reducing the cancer's metastatic potential
Environmental mercury (Hg) contamination is a global concern requiring action at national scales. Scientific understanding and regulatory policies are underpinned by global extrapolation of Northern Hemisphere Hg data, despite historical, political, and socioeconomic differences between the hemispheres that impact Hg sources and sinks. In this paper, we explore the primary anthropogenic perturbations to Hg emission and mobilization processes that differ between hemispheres and synthesize current understanding of the implications for Hg cycling.
View Article and Find Full Text PDF