Publications by authors named "C De Cristofano"
Aims: In treating patients with melanoma, the order in which therapy is administered, choosing between targeted therapy and immune checkpoint inhibition, has garnered growing interest.
Patients And Methods: We conducted a retrospective, real-world analysis of patients with advanced melanoma undergoing immunotherapy or targeted therapy as first-line at a single center.
Results: A total of 88 patients diagnosed with melanoma were identified.
Osteosarcoma (OS) is the most prevalent malignant bone tumor in adolescents and young adults. OS cells grow in a permissive local microenvironment which modulates their behavior and facilitates all steps in tumor development (e.g.
View Article and Find Full Text PDFCutaneous malignant melanoma (MM) is the most aggressive form of skin cancer, associated with high mortality and rising incidence rates in Europe despite prevention efforts. Nodular MM, the most aggressive subtype, often mimics other skin tumors, complicating diagnosis. We present the case of a 66-year-old woman with a large, ulcerated tumor beneath the left scapula, along with multiple nodular lesions on the left arm and chest.
View Article and Find Full Text PDFArticle Synopsis
- Immunotherapy is important for treating recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), but few patients experience long-term benefits due to an immunosuppressive tumor environment.
- This study investigated how the expression of the protein CD73 by both cancer and immune cells influences the effectiveness of anti-PD-1 immunotherapy in patients.
- Results showed that high CD73 levels on cancer cells are linked to early disease progression, suggesting that evaluating CD73 could help identify patients who are likely to resist treatment.
Article Synopsis
- Lipopolysaccharide (LPS) and its binding protein LBP are linked to the transition from obesity to metabolic diseases like NAFLD, with LPS promoting liver inflammation and LBP playing a complex role in disease progression.
- A study involving 186 participants found that higher LBP levels were present in obese individuals, but these levels were negatively correlated with glucose metabolism, indicating a potential protective function against type 2 diabetes (T2D).
- Overall, increased LBP may aid in LPS degradation in the liver, suggesting that higher LBP levels in obese individuals could actually be associated with better metabolic health and a lower risk of NAFLD/NASH.