Publications by authors named "C Daubenberger"
Background: The RTS,S/AS01 malaria vaccine showed lower antibody response and protective efficacy in infants aged 6-12 weeks compared with children aged 5-17 months (for whom this vaccine is recommended). We aimed to study the effect of previous Plasmodium falciparum exposure on the antibody responses to RTS,S/AS01 vaccination in infants and children, and the mediating effect of baseline (including maternal) anti-circumsporozoite protein (CSP) antibodies.
Methods: In this observational study, we included children and infants from six African countries (Burkina Faso, Gabon, Ghana, Kenya, Mozambique, and Tanzania) enrolled in the MAL067 immunology ancillary study of the RTS,S/AS01 phase 3 clinical trial from March 27, 2009, to Jan 21, 2011.
RTS,S/AS01, the first approved malaria vaccine, demonstrated moderate efficacy during the phase 3 pediatric trial. We previously investigated cell-mediated immune (CMI) responses following the primary 3-dose immunization and now report responses to the booster dose given 18 months later. Thirty CMI markers were measured by Luminex in supernatants of peripheral blood mononuclear cells from 709 children and infants after RTS,S/AS01 antigen stimulation, and their associations with malaria risk and antibodies one month post-booster and one year later were assessed.
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- The PfSPZ Vaccine shows promise as a malaria vaccine, effectively providing sterile protection in both malaria-naïve and exposed adults, relying on immune responses to early liver-stage parasites.
- A study involving 21 Tanzanian adults analyzed their immune responses to the vaccine and subsequent malaria infection, revealing robust IgG and IgM reactions to specific protein targets, regardless of HIV infection status.
- The findings highlight PfMSP5 as a significant target for vaccine-induced immunity, indicating that protecting against malaria might be possible without interference from HIV, and underscoring the need for further exploration of this immunogen.
Article Synopsis
- The study explores the interaction between two common parasites, Plasmodium (which causes malaria) and soil transmitted helminths (STH), revealing mixed effects on malaria severity and outcomes.
- Children aged 2 months to 9 years in Bagamoyo, Tanzania, participated in a case control study comparing those with malaria to those with asymptomatic Plasmodium infection to investigate these interactions.
- Results indicated that while some STHs, particularly Enterobius vermicularis, showed a protective effect against malaria, hookworms were associated with an increased risk of developing clinical malaria, highlighting the complex relationship between these parasites.