Publications by authors named "C Daousi"
Background And Objectives: Intraoperative MRI (iMRI) has been demonstrated to improve the extent of resection of pituitary neuroendocrine tumors resected using endoscopic endonasal approaches. We sought to establish if preoperative clinicoradiological parameters could be used to predict which patients are most likely to benefit from iMRI and thus allow more efficient use of this technology.
Methods: A prospectively maintained surgical database of all endoscopic pituitary tumor resections with iMRI guidance performed between May 2017 and September 2023 was accessed.
Low libido despite high normal testosterone levels in a male with an FSH-secreting pituitary macroadenoma.
Endocrinol Diabetes Metab Case Rep
January 2024
Article Synopsis
- Functioning gonadotroph adenomas are rare tumors that secrete excess follicle-stimulating hormone (FSH) and often lead to sexual dysfunction and other symptoms before being diagnosed.
- A case study highlighted a 37-year-old male with FSH-secreting macroadenoma who experienced sexual difficulties, testicular issues, and later headaches and visual problems, ultimately diagnosed through imaging and hormonal tests.
- The patient underwent successful surgery, resulting in significant improvement in hormone levels and symptoms, underlining the importance of considering rare pituitary disorders in patients with atypical hypogonadal symptoms.
Pituitary incidentalomas are common findings with increasing use of modern neuroradiological imaging undertaken for symptoms unrelated to pituitary disease. The prevalence of these lesions is ∼10% in autopsy studies and the incidence varies from 10% to 38% on magnetic resonance imaging in the published literature. They are almost always benign in nature and most are non-functioning (non-secreting) adenomas.
View Article and Find Full Text PDFBackground: Extent of resection is a major determinant of outcomes following pituitary surgery. Intra-operative magnetic resonance imaging (iMRI), provides an immediate assessment of the extent of resection, allowing further tumour resection during the same procedure. However, such systems are expensive and significantly increase operative time, prompting some authors to question the additional benefit conferred by iMRI when combined with endoscopy.
View Article and Find Full Text PDFSummary: We report our experience on managing a case of florid Cushing's disease with Methicillin-resistant Staphylococcus aureus (MRSA) sepsis using intravenous etomidate in the intensive care unit of a UK district general hospital.
Learning Points: Severe Cushing's syndrome is associated with high morbidity and mortality. Etomidate is a safe and effective medical therapy to rapidly lower cortisol levels even in the context of severe sepsis and immunosuppression.