[Disseminated peritoneal leiomyomatosis. A rare disease picture].

After taking oral contraceptive hormones continuously for 17 years, a 44 year old patient developed enlarging uterine leiomyomas and multiple small to tiny subperitoneal nodules throughout the pelvic peritoneum. Histologically and immunohistochemically, the nodules proved to be leiomyomas. Similar nodules were induced in young female guinea pigs by injecting them with estradiol twice weekly.

In vitro fertilization: the degree of endometrial insufficiency varies with the type of ovarian stimulation.

Fifty-eight patients in an in vitro fertilization program who did not have embryo transfers had endometrial biopsies performed on the second day after ovulation. The patients had been stimulated with clomiphene citrate (CC) and human chorionic gonadotropin (hCG) (group I); with CC, human menopausal gonadotropin (hMG), and hCG (group II), or with hMG and hCG (group III). Only 17 patients (30%) showed a normal luteal phase histology.

[Histologic endometrial findings in patients on the day of planned embryo transfer].

Patients under study in a programme of in-vitro-fertilisation and regarded as "normocyclic" were divided into 3 groups, depending on prior therapy: Patients in group I received clomiphene for follicle stimulation, and for ovulation HCG. Those in group II received in addition HMG for follicle maturation. Those in group III received HMG and HCG.