Publications by authors named "C DEB"
Identification of the active constituents and molecular mechanism of Eulophia nuda extract in the treatment of osteoarthritis by network pharmacology, molecular modelling and experimental assays.
Naunyn Schmiedebergs Arch Pharmacol
September 2024
Osteoarthritis is a degenerative joint disease that worsens over time, often resulting in chronic pain. Eulophia nuda (Orchidaceae), a medicinal herb widely used by folklore and indigenous healers for treating arthritis but the active ingredients and the molecular mechanisms of action are yet to be explored. The present study systematically investigates the underlying anti-osteoarthritic mechanism of ENE through network pharmacology, molecular dynamics simulation and experimental assays.
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- The study examined the relationship between low disaccharidase enzyme activity and gastrointestinal symptoms, particularly in patients with irritable bowel syndrome (IBS).
- Out of 40 patients, 60% had disaccharidase deficiency, and half of those met the criteria for IBS, but most reported severe gastrointestinal symptoms regardless of enzyme levels.
- The results indicated no significant correlation between the level of disaccharidase deficiency and the severity of symptoms or the diagnosis of IBS.
Accurately predicting agricultural commodity prices is crucial for India's economy. Traditional parametric models struggle with stringent assumptions, while machine learning (ML) approaches, though data-driven, lack automatic feature extraction. Deep learning (DL) models, with advanced feature extraction and predictive abilities, offer a promising solution.
View Article and Find Full Text PDFBackground: Reduced activity of the sucrase-isomaltase (SI) enzyme can cause gastrointestinal symptoms. Biochemical measurement of SI activity in small intestinal biopsies is presently considered the gold standard for the diagnosis of SI deficiency, but this invasive test is not suitable as a routine diagnostic tool.
Aim: To evaluate a C-sucrose-breath test (CSBT) as a diagnostic tool for SI deficiency in an adult population.
Background: Recurrent upper endoscopies are essential for monitoring therapy response and disease activity in patients with eosinophilic esophagitis (EoE), leading to increased costs, procedural complications, and anesthesia exposure. The aim of this study was to examine an office-based model using serial sedation-free blind esophageal epithelial brushing (BEEB) to monitor therapy response through eosinophil-derived neurotoxin (EDN) levels and guide therapy plans in pediatric EoE patients.
Methods: EoE patients (≤21 years of age) were enrolled in this prospective study.