Reduced Representation and Whole-Genome Sequencing Approaches Highlight Beluga Whale Populations Associated to Eastern Canada Summer Aggregations.

Effective conservation strategies inherently depend on preserving populations, which in turn requires accurate tools for their detection. Beluga whales () inhabit the circumpolar Arctic and form discrete summer aggregations. Previous genetic studies using mitochondrial and microsatellite loci have delineated distinct populations associated to summer aggregations but the extent of dispersal and interbreeding among these populations remains largely unknown.

Student access patterns for an online clinical skills procedural video library.

Clinical Relevance: Clinical skills training is essential in optometry curricula to develop core graduate entry competencies, including self-directed learning to facilitate life-long learning. Efficient and efficacious approaches are required to optimise student and educator time and resources.

Background: A video library of optometric clinical skills was created in 2012 to support self-directed student learning and face-to-face training.

A semi-automated method using object-based image analysis (OBIA) to detect and enumerate beluga whales in summer from very high-resolution (VHR) satellite imagery.

Very high-resolution (VHR) satellite imagery has proven to be useful for detection of large to medium cetaceans, such as odontocetes and offers some significant advantages over traditional detection methods. However, the significant time investment needed to manually read satellite imagery is currently a limiting factor to use this method across large open ocean regions. The objective of this study is to develop a semi-automated detection method using object-based image analysis to identify beluga whales (Delphinapterus leucas) in open water (summer) ocean conditions in the Arctic using panchromatic WorldView-3 satellite imagery and compare the detection time between human read and algorithm detected imagery.

Unraveling the Genetic Legacy of Commercial Whaling and Population Dynamics in Arctic Bowhead Whales and Narwhals.

Assessing genetic structure and diversity in wildlife is particularly important in the context of climate change. The Arctic is rapidly warming, and endemic species must adapt quickly or face significant threats to persistence. Bowhead whales (Balaena mysticetus) and narwhals (Monodon monoceros) are two long-lived Arctic species with similar habitat requirements and are often seen together in the Canadian Arctic.

Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma.

Background: Muscle-invasive urothelial carcinoma is an aggressive disease with high rates of relapse. Whether pembrolizumab as adjuvant therapy would be effective in patients with high-risk muscle-invasive urothelial carcinoma after radical surgery is unknown.

Methods: In this phase 3 trial, we randomly assigned patients, in a 1:1 ratio, to receive pembrolizumab at a dose of 200 mg every 3 weeks for 1 year or to undergo observation.