Publications by authors named "C D Stringer"
Simultaneous recordings from hundreds or thousands of neurons are becoming routine because of innovations in instrumentation, molecular tools, and data processing software. Such recordings can be analyzed with data science methods, but it is not immediately clear what methods to use or how to adapt them for neuroscience applications. We review, categorize, and illustrate diverse analysis methods for neural population recordings and describe how these methods have been used to make progress on longstanding questions in neuroscience.
View Article and Find Full Text PDFThis study analyzes the effects of bioclimate and masticatory factors on the regional variability of human cranial forms across 150 ethnic groups worldwide. Morphometric variables were generated using principal component analysis applied to 3D homologous models. Relationships between cranial form and bioclimate (temperature and precipitation) and masticatory factors (infratemporal space) were tested considering sampling bias due to past population movements during the late Pleistocene and/or early- to mid-Holocene.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses the challenges in analyzing large-scale neural data and highlights the importance of visualization methods to identify activity patterns in neurons.* -
- It introduces 'Rastermap', a new visualization technique that organizes neurons based on their activity patterns and allows researchers to explore recordings from various animal models, including mice and zebrafish.* -
- The effectiveness of Rastermap is benchmarked through simulations, and the text also notes that there are specific high-dimensional scenarios where this method and similar algorithms may fail to provide clear insights.*
Article Synopsis
- Theories suggest that eye movement decisions while reading are influenced by both visual and linguistic factors.
- In experiments that masked spaces and letters, it was found that both hearing and deaf readers have similar perceptual and word identification spans but differ in reading efficiency.
- Deaf readers showed a better reading rate, especially when engaging with leftward text, indicating they might rely more on leftward visual information despite similarities in eye movement spans.
Article Synopsis
- WHaloCaMP is a new, bright calcium indicator that can be genetically targeted and multiplexed, allowing for simultaneous imaging of multiple signals in biological tissues.
- It works by using a dye-ligand that changes fluorescence based on calcium binding, significantly increasing brightness and fluorescence lifetime for better imaging quality.
- The tool has been successfully used in live imaging of calcium responses in various organisms, including flies, mice, and zebrafish larvae, demonstrating its versatility and effectiveness for studying cellular physiology.