Publications by authors named "C D Sadik"
Risk of blindness in a global cohort of patients with mucous membrane pemphigoid.
J Eur Acad Dermatol Venereol
December 2024
Background: Previous findings imply a potential positive association between BMI and all-cause mortality in individuals with psoriasis, yet direct evidence remains absent. This study aimed to fill this gap.
Methods: We utilized data from the National Health and Nutrition Examination Survey (NHANES) for the periods 2003-2006 and 2009-2014.
Intravenous Ig (IVIg) is used to treat mucous membrane pemphigoid, although its therapeutic effectivity is not sufficiently supported by randomized controlled clinical trials, and its mode of action is only insufficiently understood. We have examined the effect of IVIg in a mouse model of anti-laminin 332 mucous membrane pemphigoid and found that IVIg ameliorates both cutaneous and mucosal inflammatory lesions. Our investigation into the modes of action of IVIg in mucous membrane pemphigoid indicated effective anti-inflammatory mechanisms beyond the enhanced degradation of IgG mediated through inhibition of the FcRn.
View Article and Find Full Text PDFBackground: Prurigo nodularis (PN) presents with intensely itchy hard nodules. Despite being limited to the skin, PN was noted to be associated with systemic diseases including diabetes and chronic renal failure. In previous smaller retrospective studies, several cardiac and vascular diseases were found more frequently in patients with PN.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers used advanced imaging techniques and specific mouse models to track how different monocyte subpopulations infiltrate inflamed skin, particularly in epidermolysis bullosa acquisita (EBA) triggered by a specific antibody.
- * Findings showed that monocytes recruit similarly to inflamed skin in various reporter mice, and even when lacking key chemokine receptors (CCR2 and CX3CR1), the recruitment process and disease severity were not significantly altered.