Publications by authors named "C D Quinlan"
To (1) assess the accuracy of the Uscom BP+ oscillometric upper-arm professional blood pressure (BP) monitor in children and adolescents as per the AAMI/ESH/ISO Universal Standard (ISO 81060-2:2018); (2) assess the suitability of a non-standard cuff; and (3) assess the impact of motion artefact on device accuracy and precision. Children and adolescents were recruited to fulfil the sex/cuff distribution criteria of the Universal Standard. Single arm sequential BP measurements were used, the test device measured on deflate with an altered child/adolescent algorithm, using three standard (Extra Small, Small Adult, Adult) and, as exploratory analysis, additionally in one non-standard cuff (Wide Range; WR) (arm circumferences: 12-17, 16-24, 22-32, 22-42 cm, respectively).
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- * This quality improvement project sought to boost adherence to antibiotic guidelines for open hand injury referrals through a microlearning approach, including an infographic and a short video.
- * Results showed a significant decrease in inappropriate antibiotic use, with non-indicated prescriptions dropping from 50% to 14.3% after implementing the educational materials.
By virtue of its role in cellular proliferation, microtubule-associated serine/threonine kinase-like (MASTL) represents a novel target and a first-in-class (FIC) opportunity to provide a new impactful therapeutic agent to oncology patients. Herein, we describe a hit-to-lead optimization effort that resulted in the delivery of two highly selective MASTL inhibitors. Key strategies leveraged to enable this work included structure-based drug design (SBDD), analysis of lipophilic efficiency (LipE) and novel synthesis.
View Article and Find Full Text PDFObjective: To design and assess a visual genomic explainer focusing on plain language and engaging imagery. The explainer aimed to support doctors' comprehension of complex genomic concepts and results and act as a resource promoting the integration of genomic testing into mainstream care.
Design: Prospective genomic resource development and questionnaire.
Article Synopsis
- * A study found that as age increases, the likelihood of older adults receiving antiviral treatment decreases, with only 35.2% of those aged 90 and above receiving it.
- * Among patients aged 65 and older, those who did not receive antiviral treatment were more likely to suffer severe outcomes, indicating a need for improved antiviral access for older populations.