Publications by authors named "C D Philpott"
Article Synopsis
- The study aims to identify factors associated with cholesteatoma, a type of middle ear disease, in a large UK cohort, highlighting established risk factors like male sex and chronic ear infections, as well as less-clear associations like deprivation and smoking.
- Researchers compared 1140 cholesteatoma cases with 4551 non-cholesteatoma cases and nearly half a million healthy controls, using logistic regression to analyze demographic factors such as age, sex, and deprivation.
- The findings indicate significant associations between cholesteatoma and factors like male sex (33% higher odds), older age, and deprivation, while showing overlaps with other inflammatory ear conditions and suggesting that both common and distinct factors influence cholesteatoma development.
Background: In the absence of direct evidence supporting how to use nasal endoscopy findings to judge chronic rhinosinusitis (CRS) disease control, experts' practice patterns could provide guidance.
Methodology: Participants consisted of a diverse group of twenty-nine rhinologists. Participants were presented with every possible combination of bilateral nasal endoscopy findings represented by the modified Lund-Kennedy (MLK; range: 0-12) endoscopic scoring system and Nasal Polyp Score (NPS; range: 0-8).
Article Synopsis
- RASopathies, like neurofibromatosis type 1 (NF1), lead to continuous activation of the Ras/MAPK pathway and often feature multiple Café au Lait Macules (CALMs).
- The study aimed to identify genes related to melanocyte growth and movement by analyzing skin samples from both CALM and unaffected areas in NF1 patients, revealing the impact of specific genetic variations.
- Findings indicated that the formation of CALMs is linked to genetic losses that enhance Ras/MAPK and Wnt signaling, coupled with decreased levels of a protective protein (PEDF), which promotes cell growth and movement in NF1-associated melanoma.
Iron forms essential cofactors used by many nuclear enzymes involved in genome maintenance. However, unchaperoned nuclear iron may represent a threat to the surrounding genetic material as it promotes redox toxicity that may affect DNA integrity. Safely handling intracellular iron implies metal transfer and cofactor assembly processes based on protein-protein interactions.
View Article and Find Full Text PDFImpact of olfactory disorders on personal safety and well-being: a cross-sectional observational study.
Eur Arch Otorhinolaryngol
July 2024
Objectives: Investigate safety perceptions, quantify hazardous events, and analyse their manifestations in individuals with olfactory dysfunction through an online cross-sectional survey.
Methods: An online survey, available from 25th February to 28th September 2022, captured data on demographics, olfactory disorder causes, safety concerns, and experienced hazardous events. Distributed via Fifth Sense channels, it targeted individuals with self-claimed olfactory dysfunction.