Publications by authors named "C D Morse"

Background: For patients with suspected traumatic vertebral artery injury (TVAI), CT angiography (CTA) is the first-line screening modality. Digital subtraction angiography (DSA) serves as the confirmatory diagnostic imaging, and is the gold standard for cerebrovascular injury assessment, due to its higher sensitivity and specificity. Among patients with TVAI based on CTA who have undergone follow-up DSA, this study aims to investigate how diagnostic information with additional imaging affects clinical management.

View Article and Find Full Text PDF

[F]SF51 is a novel radioligand for imaging translocator protein 18 kDa (TSPO) that previously displayed excellent imaging properties in nonhuman primates. This study assessed its performance in human brain and its dosimetry. Seven healthy participants underwent brain PET imaging to measure TSPO binding using a two-tissue compartment model (2TCM) to calculate total distribution volume ().

View Article and Find Full Text PDF

Background: Smoking is well known for its harmful effect on the respiratory system, but whether vaping is less harmful is unknown. Therefore, the aim of this study was to assess the association of smoking/vaping habits with self-reported respiratory symptoms in vapers and cigarette smokers.

Methods: An online survey was developed and shared on different vaping and smoking social media platforms and communities.

View Article and Find Full Text PDF

Background: Inorganic polyphosphates (polyPs) are linear chains of phosphates that accelerate blood clotting. Targeting polyP has been shown to reduce thrombosis.

Objectives: To identify and characterize anti-polyP monoclonal antibodies that could be used as analytical tools and as antithrombotic agents.

View Article and Find Full Text PDF
Article Synopsis
  • The cAMP cascade is important for regulating alcohol behaviors, showing different effects with short-term vs. long-term alcohol consumption.
  • PDE4 is the main enzyme that breaks down cAMP in the brain, and a specific subtype, PDE4B, is linked to alcohol and substance use disorders.
  • The study used PET imaging in rats to show that acute alcohol increases PDE4B activity, while chronic alcohol decreases it, suggesting that PDE4B imaging could help understand and treat alcohol use disorders in humans.
View Article and Find Full Text PDF