Bridging the distance: understanding access to healthcare through stories from Gwich'in medical travellers in Northwest Territories.

In northern Canada, medical travel - the movement of patients to a larger centre to access healthcare services outside their home community - is a dominant feature of the healthcare system. This qualitative study explored the medical travel experiences of Gwich'in living above the Arctic Circle in the Gwich'in Settlement Area in Northwest Territories (NT). Data collection in 2020 comprised storytelling sessions with 10 Gwich'in medical travellers (6 female, 4 male).

Ion channel modulator DPI-201-106 significantly enhances antitumor activity of DNA damage response inhibitors in glioblastoma.

Background: Glioblastoma, a lethal high-grade glioma, has not seen improvements in clinical outcomes in nearly 30 years. Ion channels are increasingly associated with tumorigenesis, and there are hundreds of brain-penetrant drugs that inhibit ion channels, representing an untapped therapeutic resource. The aim of this exploratory drug study was to screen an ion channel drug library against patient-derived glioblastoma cells to identify new treatments for brain cancer.

Multimodal Outcomes of Early Open Extended Midline Strip Craniectomy With Bilateral Microbarrel Staving for Correction of Isolated Nonsyndromic Sagittal Synostosis.

Aim: Sagittal synostosis is the most common craniosynostosis. The aim of surgery is to preserve cognitive function and to correct the morphologic changes. In our unit, the authors offer strip craniectomy and microbarrel staving (SMB) performed at 16 to 22 weeks.

Investigation of a surrogate measure-based safety index for predicting injury crashes at signalized intersections.

Objectives: The paper develops a machine learning-based safety index for classifying traffic conflicts that can be used to estimate the frequency of signalized intersection crashes, with a focus on the more severe ones that result in fatal and severe injury. The number of conflicts in different severity levels categorized by the safety index is used as an explanatory variable for developing statistical models for pro-actively estimating crashes.

Methods: Video-derived conflicts in different severity levels between left-turning vehicles and opposing through vehicles, a well-recognized severe injury crash typology at signalized intersections, were identified by jointly integrating the indicators of frequency and severity, using an autoencoder neural network integration method to develop anomaly scores.

Aging disrupts locus coeruleus-driven norepinephrine transmission in the prefrontal cortex: Implications for cognitive and motor decline.

The locus coeruleus (LC)-prefrontal cortex (PFC) circuitry is crucial for cognition, planning, posture and mobility. This study examines the role of norepinephrine (NE) in elucidating the neurobiological basis of age-related cognitive and motor declines. Aged mice exhibited reduced spatial learning, impaired memory, decreased physical endurance, and notable changes in locomotor behavior.