Publications by authors named "C D McKeown"
Understanding transmission pathways of important opportunistic, drug-resistant pathogens, such as extended-spectrum beta-lactamase (ESBL)-producing , is essential to implementing targeted prevention strategies to interrupt transmission and reduce the number of infections. To link transmission of ESBL-producing (ESBL-EC) between two sources, single-nucleotide resolution of strains, as well as diversity within and between samples, is required. However, the microbiological methods to best track these pathogens are unclear.
View Article and Find Full Text PDFtadpoles exhibit an avoidance behavior when they encounter a moving visual stimulus. A visual avoidance event occurs when a moving object approaches the eye of a free-swimming animal at an approximately 90-degree angle and the animal turns in response to the encounter. Analysis of this behavior requires tracking both the free-swimming animal and the moving visual stimulus both prior to and after the encounter.
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- An 8-month-old infant with a history of being born prematurely was evaluated for issues related to eye movement and microcephaly.
- The eye examination indicated a condition known as Duane syndrome, characterized by abnormal eye movements.
- Genetic testing confirmed the presence of a mutation linked to Rubinstein-Taybi syndrome type II, which is unusual but can be associated with Duane syndrome due to potential cranial nerve involvement.
The therapeutic efficacy of donor lymphocyte infusions (DLIs) given after allogeneic hematopoietic cell transplantation (HCT) is limited by risk of graft-versus-host disease (GVHD). Post-transplantation cyclophosphamide (PTCy) effectively prevents severe GVHD, but there are limited data on outcomes of DLIs given to PTCy-treated patients. We reviewed 162 consecutive PTCy-treated patients transplanted between 2015-2022 within the Center for Immuno-Oncology at the National Cancer Institute.
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