Publications by authors named "C D Mazer"
Background: There is controversy surrounding the effectiveness of red blood cell (RBC) transfusion for treating anemia in patients hospitalized for acute coronary syndromes (ACS), particularly as hemoglobin (Hb) levels approach and drop below the range of moderate anemia.
Methods: This population-based cohort study followed all adults hospitalized for ACS who experienced an in-hospital nadir Hb between 6.0 and 8.
Background: Cardiac surgery invariably triggers acute kidney stress causing adverse renal outcomes. The AKITA study evaluated the efficacy and safety of RMC-035, a novel analogue of alpha-1-microglobulin, for reducing cardiac surgery-associated kidney injury.
Methods: In this randomised double-blind placebo-controlled phase 2a study, we randomly assigned (1:1) adult hospitalised patients undergoing open-chest cardiac surgery at high risk for acute kidney injury (AKI) at 21 sites in North America and Europe to receive either RMC-035 (1.
Article Synopsis
- SGLT2 inhibitors like empagliflozin can improve heart failure outcomes in type 2 diabetes, but how they work is still not well understood.
- A study involving 90 patients with coronary artery disease and type 2 diabetes assessed the effects of empagliflozin on left atrial (LA) volume and function over 6 months.
- The results showed no significant changes in LA volume or function between the empagliflozin group and the placebo group, indicating that the drug may not impact these specific heart aspects.
Article Synopsis
- Patient reported outcomes (PROs) are vital for assessing health-related quality of life in adult patients with congenital heart disease, but they are not well defined for this population.
- This study aimed to evaluate how well different PRO survey tools could distinguish between patients with Fontan circulatory failure (FCF) and those with simpler shunt lesions.
- The Kansas City Cardiomyopathy Questionnaire (KCCQ-12) showed the best ability to identify FCF, and combining it with other PRO tools further improved its effectiveness, suggesting that these measures can help inform management strategies for adult congenital heart disease patients.