Publications by authors named "C D M Griffith"
Thousands of regulatory noncoding RNAs (ncRNAs) have been annotated; however, their functions in gene regulation and contributions to cancer formation remain poorly understood. To gain a better understanding of the influence of ncRNAs on gene regulation during melanoma progression, we mapped the landscape of ncRNAs in melanocytes and melanoma cells. Nearly half of deregulated genes in melanoma are ncRNAs, with antisense RNAs (asRNAs) comprising a large portion of deregulated ncRNAs.
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- Solid organ transplant recipients (SOTRs) face a significantly higher risk of skin cancer due to long-term use of immunosuppressants, but there are no standardized screening guidelines in the U.S. for this population.
- A scoping review analyzed 36 studies published from 2019 to 2023, focusing on skin cancer risk stratification, screening protocols, and preventive treatments for SOTRs, revealing that most studies emphasize screening and chemoprevention.
- The SUNTRAC tool was identified as a validated model for assessing skin cancer risk, with various preventive strategies suggested, and the review calls for standardized guidelines and more research on patient education and the tool's validation in diverse groups.
Online Patient Resources for Birdshot Uveitis: How Readable are These Resources?
Ocul Immunol Inflamm
October 2024
Purpose: Birdshot uveitis is a rare ophthalmic condition that can be challenging to control. The readability of online patient resources may impact the management of patients with birdshot. Thus, we examined the readability of online patient resources and identified differences in readability among sources and sections of websites.
View Article and Find Full Text PDFPatients with PTEN hamartoma tumor syndrome (PHTS), a molecular diagnosis for those carrying germline PTEN pathogenic variants, have a high prevalence of benign and malignant thyroid disease. Characterizing the genomic landscape in PHTS thyroid tumors could provide insights into malignant potential and tumor progression to help optimize diagnosis, surveillance, and treatment in this population. To reveal the somatic alterations in PHTS-associated thyroid tumors, we conducted exome sequencing on 58 thyroid tumors (28 cancers, 30 benign nodules) from 19 patients with PHTS.
View Article and Find Full Text PDFIn 2015, U.K. newborn screening (NBS) laboratory guidelines were introduced to standardize dried blood spot (DBS) specimen quality acceptance and specify a minimum acceptable DBS diameter of ≥7 mm.
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