Multiparametric MRI for Assessment of the Biological Invasiveness and Prognosis of Pancreatic Ductal Adenocarcinoma in the Era of Artificial Intelligence.

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest malignant tumor, with a grim 5-year overall survival rate of about 12%. As its incidence and mortality rates rise, it is likely to become the second-leading cause of cancer-related death. The radiological assessment determined the stage and management of PDAC.

A Rare Case with Recurrent Abdominal Pain as the First Symptom: AL Amyloidosis with Colon Involvement Combined with Pulmonary Adenocarcinoma.

Background: Amyloidosis combined with lung cancer is a rare occurrence. To date, there are no reported cases of amyloid light-chain(AL) amyloidosis solely affecting the colon combined with pulmonary adenocarcinoma.

Case Summary: Here, we describe a case of a 66-year-old woman who presented with recurrent abdominal pain and was eventually diagnosed with AL amyloidosis with colon involvement and pulmonary adenocarcinoma.

Skin-Inspired and Self-Powered Piezoionic Sensors for Smart Wearable Applications.

Bio-inspired by tactile function of human skin, piezoionic skin sensors recognize strain and stress through converting mechanical stimulus into electrical signals based on ion transfer. However, ion transfer inside sensors is significantly restricted by the lack of hierarchical structure of electrode materials, and then impedes practical application. Here, a durable nanocomposite electrode is developed based on carbon nanotubes and graphene, and integrated into piezoionic sensors for smart wearable applications, such as facial expression and exercise posture recognitions.

FAM49B drives colorectal cancer progression by stabilizing c-Myc through NEK9 phosphorylation.

Colorectal cancer (CRC) ranks as the third most prevalent cancer globally and is the second leading cause of cancer mortality. FAM49B, a member of the FAM49 gene family, is a recently identified, evolutionarily conserved gene. Emerging studies indicate that FAM49B plays a role in various cancers, though its specific mechanism in CRC remains largely unexplored.

Gold nanomaterials capped with bovine serum albumin for cell and extracellular vesicle imaging.

Bovine serum albumin-capped gold nanoclusters (AuNC@BSA) are ionic, ultra-small, and eco-friendly nanomaterials that exhibit red fluorescence emission. Upon modification, these nanomaterials can serve as imaging probes with multimodal functionality. Owing to their nanoscale properties, AuNC@BSA-based nanomaterials can be readily endocytosed by cells for imaging.