Levels and Changes in Defensive Firearm Use by US Crime Victims, 1987‒2021.

To examine levels and temporal changes in the frequency of defensive gun use by US crime victims. We computed national-level counts of criminal incidents involving firearm defense during 3 periods: 1993 to 2005, 2007 to 2015, and 2016 to 2021. We also considered earlier national estimates for 1987 to 1990.

A highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model.

Abdominal aortic aneurysm (AAA) is a deadly, permanent ballooning of the aortic artery. Pharmacological and genetic studies have pointed to multiple proteins, including microsomal prostaglandin E synthase-1 (mPGES-1), as potentially promising targets. However, it remains unknown whether administration of an mPGES-1 inhibitor can effectively attenuate AAA progression in animal models.

The Effects of Moral Distress on Resilience in Pediatric Emergency Department Nurses.

Introduction: Moral distress is widespread in health care, and nurses working in high-pressure environments, such as emergency departments, experience stress at high rates. Understanding how moral distress affects pediatric emergency nursing care is essential to moderate its negative impacts. Increased resilience has been promoted as a tool to mitigate moral distress.

Analgesic effects of a highly selective mPGES-1 inhibitor.

The growing opioid use and overdose crisis in the US is closely related to the abuse of pain medications. Particularly for postoperative pain (POP), ~ 310 million major surgeries are performed globally per year. Most patients undergoing surgical procedures experience acute POP, and ~ 75% of those with POP report the severity as moderate, severe, or extreme.

Development of pharmacotherapies for abdominal aortic aneurysms.

The cardiovascular field is still searching for a treatment for abdominal aortic aneurysms (AAA). This inflammatory disease often goes undiagnosed until a late stage and associated rupture has a high mortality rate. No pharmacological treatment options are available.