Publications by authors named "C D Levit"
Background: Total Knee Arthroplasty (TKA) is frequently performed for advanced osteoarthritis, with patient-reported outcome measures (PROMs) traditionally reporting on efficacy. These subjective evaluations, although useful, may inaccurately reflect post-TKA activity levels. With technological advancements, smart implantable devices (SIDs) offer objective, real-time gait metrics, potentially providing a more accurate postoperative recovery assessment.
View Article and Find Full Text PDFBackground: The success of HER2-positive (HER2+) breast cancer treatment with trastuzumab, an antibody that targets HER2, relies on immune response. We demonstrated that TNFα induces mucin 4 (MUC4) expression, which shields the trastuzumab epitope on the HER2 molecule decreasing its therapeutic effect. Here, we used mouse models and samples from HER2+ breast cancer patients to unravel MUC4 participation in hindering trastuzumab effect by fostering immune evasion.
View Article and Find Full Text PDFArticle Synopsis
- Triple-negative breast cancer (TNBC) is characterized by the lack of hormone receptors and overexpression of ErbB-2, making treatment challenging due to its diverse nature.
- Researchers found that ErbB-2 is present in the nucleus of TNBC cells, contributing to tumor growth, and identified two forms of ErbB-2, including a variant known as ErbB-2c.
- The compound Retro-2 effectively removes these ErbB-2 variants from the nucleus, significantly hindering the growth of TNBC in various preclinical models, indicating its potential as a new treatment option for this aggressive cancer type.
Article Synopsis
- Viral entry is the initial step in the replication cycle of enveloped viruses, facilitated by specific viral glycoproteins with varying receptor affinities.
- The study utilized vesicular stomatitis virus (VSV) to assess the entry efficiencies of different glycoproteins, including those from SARS-CoV-2, Ebola, Lassa, and Chikungunya, by creating recombinant VSV viruses that express these proteins.
- Utilizing a reporter gene and live-cell substrates, the research revealed that glycoproteins needing more priming generally resulted in slower entry times, while also enabling the analysis of receptor preferences and endocytosis mechanisms for a better understanding of viral entry.