What is the multifactorial efficacy of day-zero ambulation post-total hip replacement surgery: A systematic review.

Objective: To examine the multi-factorial efficacy of day-zero ambulation following primary total hip arthroplasty.

Data Sources: MEDLINE, CINAHL, AMED, EMBASE and APA PsychInfo in accordance with PRISMA guidelines.

Review Methods: Studies were classified for study design and ranked in a hierarchy of evidence.

In-person peer support for critical care survivors: The ICU REcovery Solutions cO-Led through surVivor Engagement (ICURESOLVE) pilot randomised controlled trial.

Background: Peer support is a promising intervention to mitigate post-ICU disability, however there is a paucity of rigorously designed studies.

Objectives: The objective of this study was to establish feasibility of an in-person, co-designed, peer-support model.

Methods: Prospective, randomised, adaptive, single-centre pilot trial with blinded outcome assessment, conducted at a university-affiliated hospital in Melbourne, Australia.

Molecular Imprinting of Benzylpiperazine: A Comparison of the Self-Assembly and Semi-Covalent Approaches.

Molecularly imprinted polymers (MIPs) for benzylpiperazine (BZP, ), an illicit designer drug, were developed by using both self-assembly and semi-covalent approaches. From an array of potential functional monomers (FMs) and using a combination of pre-synthetic interaction studies (by molecular modelling and NMR analysis) and binding assays, the highest performing self-assembly -MIPs were confirmed to result from methacrylic acid () as FM, ethylene glycol dimethacrylate (EGDMA) or trimethylolpropane trimethacrylate (TRIM) as crosslinkers and chloroform as the porogen and rebinding solvent at template (T): FM ratios of 1:1 and 1:2, giving imprinting factors (IF) 3 to 7. The semi-covalent -MIPs were designed using benzylpiperazine (4-vinylphenyl) carbamate () as the template-monomer adduct in combination with either EDGMA or TRIM.

Molecular Imprinting Using a Functional Chain Transfer Agent.

This study demonstrates the feasibility of molecular imprinting using a functional chain transfer agent sans a functional monomer. Ethylene glycol dimethacrylate (EGDMA)-based MIPs were synthesised in the presence of thioglycolic acid (TGA) possessing a carboxylic acid group, capable of interacting with the chosen test template ,-(±)-propranolol (PNL) and a labile S-H bond to facilitate an efficient chain transfer reaction. Quantitative H NMR measurements showed high PNL and TGA incorporation within the MIP, indicating an efficient chain transfer process and a favourable interaction between PNL and TGA.