Prevention of early ventilation-acquired pneumonia (VAP) in comatose brain-injured patients by a single dose of ceftriaxone: PROPHY-VAP study protocol, a multicentre, randomised, double-blind, placebo-controlled trial.

Introduction: Ventilator-associated pneumonia (VAP) is the first cause of healthcare-associated infections in intensive care units (ICUs) and brain injury is one of the main risk factors for early-onset VAP. Antibiotic prophylaxis has been reported to decrease their occurrence in brain-injured patients, but a lack of controlled randomised trials and the risk of induction of bacterial resistance explain the low level of recommendations. The goal of this study is to determine whether a single dose of ceftriaxone within the 12 hours postintubation after severe brain injury can decrease the risk of early-onset VAP.

[First intention management of obstructive sleep apnea syndrome (OSAS) by custom-made mandibular advancement device: the medium-term results. Prospective study by the General Hospital Pneumologists College (CPHG)].

Objectives: To demonstrate the efficacy and tolerance of present generation mandibular advancement devices in the first intention treatment for obstructive sleep apnea syndrome (OSAS), even when severe, after one year.

Methods: Between June 2006 and December 2007, 152 patients (male: 77%; age: 50.9±10.

[Bilateral pleural thickening pseudo-tumour due to tuberculosis].

The authors report the case of a 20 year old Senegalese woman in whom pulmonary and bone tuberculosis presented as bilateral, lobulated pleural thickening without effusion, associated with a vertebral abscess at D 9-10. The diagnosis was obtained by histological examination of a CT guided pleural biopsy. After 12 months treatment there was complete resolution of the pleural disease.

[Endobronchial localization of Launois Bensaude syndrome].

Launois Bensaude syndrome is a benign, asymetric lipomatosis involving the upper back, shoulders, neck and arms. The disorder is usually asymptomatic although mediastinal lipomas, extrinsic compression of trachea, obstructive sleep apnea syndrome have been described. We report for the first time to our knowledge a case of Launois Bensaude syndrome with bronchial submucosal adiposis infiltration presenting as flask, smooth, begnin tumor like formation involving several bronchi.

[Radiological evidence of lung involvement in metal fume fever].

We report the case of a 32-year-old welder who developed a flu-like syndrome a few hours after founding zinc. The patient experienced fever, headache, muscle pain and dyspnea that resolved spontaneously with a few hours. The diagnosis of metal fume fever was retained.