Publications by authors named "C D Galassi"
Article Synopsis
- Hormone receptor-positive breast cancer shows limited response to immune checkpoint inhibitors (ICIs), but radiation therapy (RT) might enhance the effectiveness of ICIs by boosting immune responses.
- The study explored the combination of hypofractionated RT with ICIs in a mouse model to see if targeting the primary tumor could delay the emergence of new tumors.
- Results revealed that while focal RT could control primary tumor growth effectively, adding ICIs did not significantly improve overall survival, suggesting that controlling the primary tumor does not necessarily prevent the development of new cancer lesions.
Article Synopsis
- * Key functions of DCs, such as their ability to phagocytize material and express CTL-activating ligands, are vital for immuno-oncology studies but are hindered by the cells' inability to be cultured indefinitely in the lab.
- * The authors present a new method using a conditionally immortalized DC line that can be easily activated and maintained in culture, allowing for high-throughput screening of potential DC activators without the variabilities of freshly generated DCs.
Article Synopsis
- The "three Es" model describes how the immune system keeps cancer cells in check until they gain traits that allow them to escape immune detection.
- A new framework called the "three Cs" explains how cancer cells evade the immune system through camouflage, coercion, and cytoprotection.
- Improving cancer treatments requires blocking these escape mechanisms to enhance the effectiveness of both immunotherapy and conventional therapies.
Cancer stem cells (CSCs) are a poorly differentiated population of malignant cells that (at least in some neoplasms) is responsible for tumor progression, resistance to therapy, and disease relapse. According to a widely accepted model, all stages of cancer progression involve the ability of neoplastic cells to evade recognition or elimination by the host immune system. In line with this notion, CSCs are not only able to cope with environmental and therapy-elicited stress better than their more differentiated counterparts but also appear to better evade tumor-targeting immune responses.
View Article and Find Full Text PDF