An evaluation of a 9th and 10th grade Native American virtual pilot: Utilizing a culturally responsive and Inclusive Science model.

STEM pipeline programs that pair underrepresented youth with culturally responsive mentors have been shown to support students' science identity development, belonging, and persistence. Yet, most scholarship focuses on undergraduates and advanced high schoolers. Funded by the National Institute of Diabetes, Digestive and Kidney Disease, the STEP-UP Pilot recruited a cohort of 9th and 10th grade American Indian students to participate in a mentored introductory research experience.

Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.

Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality with both monogenic and polygenic components. Here, we report results from a large genome-wide association study and multitrait analysis including 5,900 HCM cases, 68,359 controls and 36,083 UK Biobank participants with cardiac magnetic resonance imaging. We identified 70 loci (50 novel) associated with HCM and 62 loci (20 novel) associated with relevant left ventricular traits.

Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings.

Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality, with pathogenic variants found in about a third of cases. Large-scale genome-wide association studies (GWAS) demonstrate that common genetic variation contributes to HCM risk. Here we derive polygenic scores (PGS) from HCM GWAS and genetically correlated traits and test their performance in the UK Biobank, 100,000 Genomes Project, and clinical cohorts.

Development, dissemination and community response towards the first community notice regarding misrepresented illicit anabolic-androgenic steroids in circulation in Australia.

Introduction: Drug alerts aimed at both people who use drugs and health workers help to prevent acute harms from unpredictable illicit drug markets and by equipping health workers to handle unusual drug events and share vital information with service users. However, there has never been an alert produced for anabolic-androgenic steroids (AAS), an important class of illicit drugs. We report on the development, implementation and community receptivity of the first-ever AAS community drug alert.

The world's first anabolic-androgenic steroid testing trial: A two-phase pilot combining chemical analysis, results dissemination and community feedback.

Background And Aims: The clandestine production and distribution of anabolic-androgenic steroids (AAS) poses health risks due to the uncertainty of their contents. This study aimed to test the chemical content of AAS samples and provide aggregate results back to the community, exploring how these results influenced usage decisions and risk management.

Design: A mixed-methods approach was used, combining chemical analysis of AAS samples with qualitative interviews.