Outpatient parenteral antibiotic therapy with elastomeric pumps, what is the flowrate accuracy?

Background: Outpatient Parenteral Antibiotic Therapy (OPAT) services have expanded throughout the world thanks to elastomeric pumps (EP). Their flowrate is known to vary by ±15%. Treatment effectiveness and the organization of care at home may be impacted, especially with piperacillin/tazobactam infusion (TAZ).

Systematic characterization of faecal sludge from various sources for its use as a solid fuel.

Faecal sludge (FS) is not extensively evaluated for its potential as a solid fuel mainly due to the general conception of its "highly variable characteristics" in relation to the wide range of on-site sanitation systems. An extensive and systematic FS characterization was therefore conducted on twenty-four samples collected directly from pit latrines, ventilated improved pit latrines (VIPs) and urine-diverting dehydrating toilets (UDDTs) at two depths to understand the impact on properties relevant for combustion. The higher heating value (HHV) for these samples lies between 13 to 22 MJ/kg DM (dry matter).

The GacS/GacA two-component system strongly regulates antimicrobial competition mechanisms of MFE01 strain.

Unlabelled: MFE01 is an environmental bacterium characterized by an hyperactive type 6 secretion system (T6SS) and a strong emission of volatile organic compounds (VOCs). In a previous study, a transposition mutant, 3H5, exhibited an inactive T6SS and altered VOC emission. In 3H5, the interruption of gene by the transposon was insufficient to explain these phenotypes.

Microrheometric study of damage and rupture of capsules in simple shear flow.

Capsules, which are potentially-active fluid droplets enclosed in a thin elastic membrane, experience large deformations when placed in suspension. The induced fluid-structure interaction stresses can potentially lead to rupture of the capsule membrane. While numerous experimental studies have focused on the rheological behavior of capsules until rupture, there remains a gap in understanding the evolution of their mechanical properties and the underlying mechanisms of damage and breakup under flow.

Neglected class A carbapenemases: Systematic review of IMI/NmcA and FRI from a One Health perspective.

Carbapenemase-producing Enterobacterales are pathogens classified as a critical priority by the World Health Organization and a burden on human health worldwide. IMI, NmcA, and FRI are under-detected class A carbapenemases that have been reported in the human, animal and environmental compartments, particularly these last 5 years. Bacteria producing these carbapenemases have been mostly identified in digestive carriage screenings, but they are also involved in severe infections, such as bacteremia.