Publications by authors named "C D Conover"
Article Synopsis
- High-dose testosterone replacement therapy (TRT) combined with finasteride offers benefits such as improved body composition, muscle strength, and bone density in older men, while mitigating the risk of prostate enlargement.
- A pilot study involved 12 men with spinal cord injuries, demonstrating that TRT with finasteride significantly increased lean body mass and muscle size, alongside enhancing bone mineral density compared to a placebo.
- Results suggest TRT + finasteride reduced fat mass and improved muscular strength, with measurable benefits observed as early as 6 months into the treatment, indicating its potential effectiveness for men with low testosterone post-injury.
Article Synopsis
- * The study reveals that TDMASn degrades into another compound, bis(dimethylamido)tin(II), but this degradation does not affect the film growth or structure.
- * Despite unaffected growth, the degradation leads to a significant increase in electrical resistance and reduces the efficiency of perovskite solar cells, highlighting the need for stabilizing TDMASn or finding new materials for better device performance.
Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular disease.
Growth Horm IGF Res
December 2024
There is strong evidence that PAPP-A, a local regulator of insulin-like growth factor signaling through proteolytic cleavage of inhibitory binding proteins, is involved in multiple physiological processes associated with cardiovascular disease. This review will describe the various roles of PAPP-A with a focus on atherosclerosis, neointimal hyperplasia, and acute coronary syndrome in animal models and in humans.
View Article and Find Full Text PDFThere is strong evidence that insulin-like growth factor (IGF) signaling is involved in fundamental aspects of the aging process. However, the extracellular part of the IGF system is complex with various receptors, ligand effectors, high affinity IGF binding proteins, proteinases and endogenous inhibitors that all, along with their biological context, must be considered. The IGF system components are evolutionarily conserved, underscoring the importance of understanding this system in physiology and pathophysiology.
View Article and Find Full Text PDFArticle Synopsis
- Alzheimer's disease (AD) is a worsening brain condition without effective treatments, linked to the buildup of toxic β-amyloid peptides and amyloid plaques.
- Previous studies have connected the insulin-like growth factor (IGF) system to AD, and reduced IGF-I receptor (IGFIR) signaling can alleviate plaque formation and neurodegeneration in mice.
- Research highlighted that deleting PAPP-A, a protein involved in regulating IGF-I, in a mouse model of AD resulted in less plaque, improved brain function, and suggests that targeting PAPP-A could be a new treatment option for AD.