Sphingosine-1-phosphate receptor 3 activation promotes sociability and regulates transcripts important for anxiolytic-like behavior.

We previously demonstrated that sphingosine-1-phosphate receptor 3 (S1PR3) in the medial prefrontal cortex (mPFC) prevents reductions in sociability normally caused by stress. S1PR3 is a ubiquitously expressed G-protein coupled receptor that regulates immune system function, although its regulation of other biological processes is not well understood. Pharmacological activators of S1PR3 might provide important insights for understanding the neural substrates underlying sociability.

Military spouse and key stakeholder perspectives of effective messaging for US service members on secure storage of personal firearms: a qualitative study.

Background: Secure firearm storage is a proposed method for reducing intentional and unintentional firearm injury and death among US military service members. However, little is known about suggested key messengers and optimal message content to promote secure firearm storage practices among at-risk US service members. This qualitative study focused on military spouse and stakeholder perspectives concerning key messengers and message content for the delivery of effective messaging around promoting secure firearm storage practices among US service members.