Publications by authors named "C D Brewer"
Lassa virus (LASV) belongs to the Arenavirus family. LASV is endemic in several West Africa countries and causes viral hemorrhagic fevers. The Nigeria CDC has reported that an outbreak in 2024 in 28 states has resulted in 7767 suspected cases of Lassa fever, 971 confirmed cases and 166 confirmed deaths up to 11 August.
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- The study aimed to evaluate the efficacy, safety, and tolerability of brexpiprazole for treating borderline personality disorder (BPD), as no approved drugs exist for this condition.* -
- In a randomized, double-blind trial, 324 adult patients with BPD were given either brexpiprazole or a placebo for 11 weeks, but the results showed no significant difference between the two groups on the primary outcome measure.* -
- While brexpiprazole did not meet the primary study goal, some positive signals for efficacy were noted at different time points, indicating that further research is needed, especially considering safety concerns like akathisia (restlessness) reported more frequently in brexpipraz
SRY+ Derivative X Chromosome in a Female With Apparently Typical Sexual Development.
Mol Genet Genomic Med
November 2024
Background: When the SRY gene is present in a 46,XX fetus, some degree of testicular development is expected. Our laboratory performed prenatal genetic testing for a fetus that had screened positive for Y chromosome material by noninvasive prenatal screening (NIPS) but that had apparently typical female development by ultrasound imaging. The aim of this study was to determine the clinical relevance of the NIPS results.
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- African Americans with type 2 diabetes face healthcare disparities, and existing diabetes self-management programs lack cultural relevance; thus, Peers EXCEL was developed to integrate elements from two programs, HLWD and Peers LEAD.
- The study gathered insights from African American participants and facilitators through focus groups and interviews to evaluate the proposed Peers EXCEL program.
- Feedback indicated a strong appreciation for the cultural alignment of Peers EXCEL, highlighting the need to address issues like systemic racism and the inclusion of community perspectives in creating effective diabetes management programs.
Article Synopsis
- The study aimed to compare the time until relapse in patients with major depressive disorder (MDD) who continued or withdrew brexpiprazole after stabilizing on antidepressants.* -
- In a Phase 3 clinical trial involving 1149 patients, those who received either continued brexpiprazole or placebo showed similar median relapse times of 63 days, with around 80% remaining relapse-free at the end of the study.* -
- The findings suggest that whether patients continued brexpiprazole or switched to a placebo, the outcomes were similar, and the treatment was generally well tolerated with minimal side effects.*