Publications by authors named "C D Bae"
The incidence of mammary gland tumors in dogs is a significant issue, characterized by notable rates of malignancy, recurrence, and disease burden. However, the lack of comprehensive information and correlated studies has presented challenges in establishing an effective surgical treatment strategy. In this study, a cohort of 95 dogs diagnosed with mammary tumors underwent evaluation using various surgical methods, medications, ovariohysterectomy, and assessments of margin completeness to analyze clinical outcomes.
View Article and Find Full Text PDFInhibition of lactate dehydrogenase (LDH) has emerged as a promising cancer therapy strategy due to its essential role in the metabolic transformation of cancer cells. In this study, 53 derivatives of 1-hydroxy(and 1-alkoxy, 1-acyloxy)indoles were designed, synthesized, and biologically evaluated. Several multi-substituted 1-hydroxy(and 1-alkoxy, 1-acyloxy)indole compounds exhibited inhibitory activity against the LDH-A isoform (LDHA).
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- Sepsis is a serious medical condition, and despite numerous clinical trials, finding effective treatment strategies is difficult due to small-scale testing; this study aims to extract optimal treatments from existing patient records.
- Using a modified deep reinforcement learning algorithm, researchers developed an AI model trained on over 16,000 hospital admissions, with performance tested through various statistical analyses and visualizations.
- The model showed a significant increase in estimated survival rates (up to 10.03%) and exhibited different treatment strategies compared to physicians, highlighting key factors like blood urea nitrogen and age, and indicating that while promising, results may need further clinical testing before implementation.
Article Synopsis
- Hyperuricemia, an imbalance of uric acid, leads to diseases like gout, which can be treated with drugs, although they may have side effects.
- The study utilized both test tubes and animal models to investigate the effects of Korean red ginseng water extract (KRGWE) on hyperuricemia in mice, comparing it to traditional treatment with allopurinol.
- KRGWE showed a dose-dependent ability to reduce serum uric acid levels by enhancing uric acid excretion genes and inhibiting reabsorption genes, also contributing to improved liver and kidney function.