Publications by authors named "C D Amdal"
Background And Purpose: To present the clinical outcomes of two series of patients treated with carbon-ion radiotherapy (CIRT) and definitive photon radiotherapy (RT) for adenoid cystic carcinoma of the head and neck (HN-ACC).
Material And Methods: The first cohort of six patients was referred from Oslo University Hospital (OUS) to Centro Nazionale di Adroterapia Oncologica (CNAO, Pavia, Italy) for CIRT in 2014-2017. The second cohort included 18 patients treated with definitive photon RT at OUS in 2005-2017.
Background: Patient-reported outcomes (PROs) play an increasing role in the evaluation of oncology treatments. At the same time, single-arm trials are commonly included in regulatory approval submissions. Because of the high risk of biases, results from single-arm trials require careful interpretation.
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- The study focused on establishing minimal important change (MIC) estimates for quality of life (QoL) in head and neck cancer patients using the EORTC QLQ-HN43 questionnaire.
- A total of 503 patients from 15 countries completed the questionnaire at three different time points during treatment, and results indicated varying MICs for different QoL domains such as swallowing, speech, and dry mouth.
- Findings revealed that MIC values for deterioration were generally higher than those for improvement, implying that a universal MIC or minimal detectable change (MDC) cannot be uniformly applied across all scales of the EORTC QLQ-HN43.
Background: There is lack of evidence on chronic fatigue (CF) following radiotherapy (RT) in survivors of head and neck cancer (HNC). We aimed to compare CF in HNC survivors > 5 years post-RT with a reference population and investigate factors associated with CF and the possible impact of CF on health-related quality of life (HRQoL).
Material And Methods: In this cross-sectional study we included HNC survivors treated in 2007-2013.
Head and neck cancer (HNC) patients suffer from a range of health-related quality of life (HRQoL) issues, but little is known about their long-term HRQoL. This study explored associations between treatment group and HRQoL at least 5 years' post-diagnosis in HNC survivors. In an international cross-sectional study, HNC survivors completed the European Organization for Research and Treatment of Cancer (EORTC) quality of life core questionnaire (EORTC-QLQ-C30) and its HNC module (EORTC-QLQ-H&N35).
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