Alcohol-related stimuli disrupt inhibitory control in heavy but not light drinkers in a crowdsourced sample.

The association between inhibitory control and alcohol use has been well established. However, studies comparing the effects of alcohol cues on disinhibition in heavy and light drinkers have reported mixed results. The present study used a crowdsourcing platform, Prolific, to assess the effects of alcohol-related cues on inhibitory control in light drinkers versus heavy drinkers.

Engineering of increased L-Threonine production in bacteria by combinatorial cloning and machine learning.

The goal of this study is to develop a general strategy for bacterial engineering using an integrated synthetic biology and machine learning (ML) approach. This strategy was developed in the context of increasing L-threonine production in ATCC 21277. A set of 16 genes was initially selected based on metabolic pathway relevance to threonine biosynthesis and used for combinatorial cloning to construct a set of 385 strains to generate training data (i.

PT150 blocks the rewarding properties of ethanol and attenuates ethanol-induced reduction of egg laying in Coturnix quail.

Rationale: Alcohol use disorder (AUD) has been shown to be associated with a dysregulated stress system. Reducing the stress hormone corticosterone (CORT), that binds to glucocorticoid receptors, may attenuate the rewarding properties of drugs of abuse. However, the effect of blocking corticosterone receptors on ethanol reward has yet to be investigated.

Fixed-target serial crystallography at the Structural Biology Center.

Serial synchrotron crystallography enables the study of protein structures under physiological temperature and reduced radiation damage by collection of data from thousands of crystals. The Structural Biology Center at Sector 19 of the Advanced Photon Source has implemented a fixed-target approach with a new 3D-printed mesh-holder optimized for sample handling. The holder immobilizes a crystal suspension or droplet emulsion on a nylon mesh, trapping and sealing a near-monolayer of crystals in its mother liquor between two thin Mylar films.

Time will tell: Temporal processing in the sexual behavior system.

This paper describes several temporal factors that appear to play a role in sexual conditioning including the conditioned stimulus (CS)-unconditioned stimulus (US) interval, the C/T ratio, and trace conditioning. One commonality among these studies is the attention given to the stimuli and responses involved. This is contrary to traditional learning theories such as the general process theory.