Publications by authors named "C D Abeyrathne"
Article Synopsis
- Researchers used an inverse-micelle sol-gel method to create Ti and Fe-doped mesoporous silica catalysts for oxidizing styrene to benzaldehyde.
- The Ti-doped catalyst (Ti-MS) showed impressive results, achieving 93% conversion of styrene and 91% selectivity for benzaldehyde, while also producing minor byproducts like formic acid and acetophenone.
- The catalysts maintained their effectiveness over four reuse cycles, highlighting the importance of acid strength and choice of solvents and oxidants for optimal performance.
Malaria elimination is a global public health priority. To fulfil the demands of elimination diagnostics, we have developed an interdigitated electrode sensor platform targeting the Plasmodium falciparum Histidine Rich Protein 2 (PfHRP2) protein in saliva samples. A protocol for frequency-specific PfHRP2 detection in phosphate buffered saline was developed, yielding a sensitivity of 2.
View Article and Find Full Text PDFPre-treatment screening of individuals for human leukocyte antigens (HLA) HLA-B*57:01 is recommended for the prevention of life-threatening hypersensitivity reactions to abacavir, a drug widely prescribed for HIV treatment. However, the implementation of screening in clinical practice is hindered by the slow turnaround time and high cost of conventional HLA genotyping methods. We have developed a biosensor platform using interdigitated electrode (IDE) functionalized with a monoclonal antibody to detect cells expressing HLA-B*57:01.
View Article and Find Full Text PDFElimination of malaria is a global health priority. Detecting an asymptomatic carrier of parasites to receive treatment is an important step in achieving this goal. Current available tools for detection of malaria parasites are either expensive, lacking in sensitivity for asymptomatic carriers, or low in throughput.
View Article and Find Full Text PDFArticle Synopsis
- Screening for the HLA-B*15:02 allele can prevent dangerous allergic reactions to carbamazepine, but traditional testing methods are costly and slow.
- A new biosensor platform utilizing loop-mediated isothermal amplification (LAMP) allows for rapid and efficient detection of this allele without the need for DNA extraction or complex procedures.
- In testing with 27 blood samples, this LAMP-IDE platform showed high sensitivity (92.9%) and good specificity (84.6%), indicating its potential for point-of-care applications to improve screening access.