Publications by authors named "C D A Stehouwer"
Fasting plasma methylglyoxal concentrations are associated with higher numbers of circulating intermediate and non-classical monocytes but with lower activation of intermediate monocytes: the Maastricht Study.
J Endocrinol Invest
January 2025
Purpose: Elevated methylglyoxal (MGO) levels and altered immune cell responses are observed in diabetes. MGO is thought to modulate immune cell activation. The current study investigated whether fasting or post-glucose-load plasma MGO concentrations are associated with circulating immune cell counts and activation in a large cohort study.
View Article and Find Full Text PDFThe mediating role of the food environment, greenspace, and walkability in the association between socioeconomic position and type 2 diabetes - The Maastricht Study.
Diabetes Metab Syndr
December 2024
Article Synopsis
- The study examines how socioeconomic position (SEP), food environments, walkability, and greenspace impact type 2 diabetes (T2D) risk, focusing on their interconnection.
- Lower SEP correlates with a higher risk of T2D, with significant hazard ratios indicating a strong link between education, income, occupation, and diabetes prevalence.
- Environmental factors only weakly mediate the relationship between SEP and T2D, suggesting that while lower SEP leads to a less healthy environment, this isn't the primary driver for increased diabetes risk.
Objective: Glucose metabolism status (GMS) is linked to non-alcoholic fatty liver disease (NAFLD). Higher levels of advanced glycation end products (AGEs) are observed in people with type 2 diabetes mellitus (T2DM) and NAFLD. We examined the association between GMS, non-invasive tests and AGEs, with liver steatosis and fibrosis.
View Article and Find Full Text PDFObjective: Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiometabolic diseases. Here, we examined the association of Type D traits with 230 (predominantly) lipid metabolites and metabolite ratios.
Methods: Four Dutch cohorts were included, comprising 10,834 individuals.
Objectives: This study aimed to examine the relationship between measures of kidney function and impaired lung function in individuals with diabetes and to assess all-cause mortality risk associated with having chronic kidney disease (CKD) and or impaired lung function.
Design: Cross-sectional and retrospective cohort study.
Setting: The National Health and Nutrition Examination Survey 2007-2012.