A multicenter evaluation of gentamicin therapy in the neonatal intensive care unit.

Study Objective: To evaluate traditional nomogram (TN) versus individualized pharmacokinetic gentamicin dosing practices in neonatal intensive care units, focusing on achieving target therapeutic concentrations (peak > 8 microg/ml, trough < 2 microg/ml), number of dosing changes, number of concentrations obtained, and evidence of nephrotoxicity.

Design: Retrospective chart review.

Setting: Three neonatal intensive care units.