Publications by authors named "C Crum"
Article Synopsis
- - STK11 adnexal tumours are rare malignant neoplasms associated with Peutz-Jeghers syndrome, primarily arising from para-adnexal soft tissues and potentially affecting the fallopian tube and ovary; diagnosis currently involves identifying STK11 mutations.
- - Researchers conducted immunohistochemistry (IHC) on 122 tumours, including 17 STK11 adnexal tumours and 105 lookalikes; results showed that STK11 adnexal tumours had complete loss of STK11 protein expression, while other tumour types generally retained it.
- - The study concludes that STK11 serves as a sensitive and specific marker for distinguishing STK11 adnexal tumours
Ewing sarcoma is an uncommon neoplasm considered in the differential diagnosis of tumors with "small round cell" morphology, but its occurrence in the gynecologic tract has only been sporadically documented. Herein, we describe the largest cohort of Ewing sarcoma localized to the female genital tract to date, and emphasize their clinicopathologic resemblance to more common gynecologic neoplasms. Ewing sarcoma (n=21) was retrospectively identified from 5 institutions.
View Article and Find Full Text PDFMost extrauterine high-grade serous carcinomas (HGSCs) are thought to develop first in the distal fallopian tube. Most models of HGSC assume origin from relatively stable, noninvasive serous tubal intraepithelial carcinomas. However, widespread tumor involvement in the absence of a serous tubal intraepithelial carcinoma could occur after catastrophic genomic events (CGEs; such as chromothripsis or polyploidy).
View Article and Find Full Text PDFCervical glandular neoplasms represent a heterogeneous group of tumors for which a comprehensive overview of the involvement of high-risk human papillomaviruses (HPV) in pathogenesis is still lacking. We first searched MEDLINE (PubMed), Embase, and Scopus databases (until October 2022), and systematically reviewed available literature. We then quantitatively estimated both pooled and genotype-specific prevalence of HPV DNA as well as the influence of various factors (e.
View Article and Find Full Text PDFArticle Synopsis
- Scientists have found that high-grade serous ovarian cancer (HGSOC) mostly starts in the fallopian tubes instead of the ovaries, but why this happens is still a mystery.
- The study shows that cells in the fallopian tubes are different from those on the ovarian surface, which helps explain why cancers arise from the tubes.
- They discovered that these fallopian tube cells have more problems dealing with stress and repairing DNA, and certain genetic factors make the cancer even worse, especially after menopause.