Publications by authors named "C Crowe"
Background: Perilunate/lunate injuries are frequently misdiagnosed. We hypothesize that utilization of a machine learning algorithm can improve human detection of perilunate/lunate dislocations.
Methods: Participants from emergency medicine, hand surgery, and radiology were asked to evaluate 30 lateral wrist radiographs for the presence of a perilunate/lunate dislocation with and without the use of a machine learning algorithm, which was used to label the lunate.
Purpose: Brachial plexus traction injuries have conventionally been categorized as involving the C5-C6, C5-C7, C5-T1, and C8-T1 roots. In this article, we report a distinct clinical presentation of brachial plexus injury characterized by intact finger flexion with signs of complete brachial plexus injury.
Methods: From 2010 to 2022, 989 patients who sustained brachial plexus injuries were examined and underwent surgery.
Article Synopsis
- Medication adjustments for Parkinson's disease are based on patient feedback and clinicians' assessments of motor symptoms like bradykinesia and tremor.
- This study evaluates how consistently different clinicians assess upper limb motor function in Parkinson's patients during video recordings of standardized hand movements.
- Results show that initial agreement among clinicians was poor, especially for certain movements, but training improved their consistency in ratings significantly.
Article Synopsis
- Small-molecule degraders can effectively target and degrade disease-driving proteins, offering a new approach for treating previously untreatable conditions.
- Researchers used cryo-EM to observe how the degrader MZ1 helps position the Brd4 protein for ubiquitination by the UBE2R1 enzyme, leading to its degradation.
- The study identifies specific lysines on Brd4 that are prone to ubiquitination and suggests a flexible model for how degrader-induced targets could be modified for better drug development.