Publications by authors named "C Coutts"
Article Synopsis
- Calcific aortic valve disease (CAVD) is a prevalent heart valve condition in older populations, with two main pathways: osteogenic and dystrophic; the latter is more common.
- The study aims to develop a new 3D dystrophic calcification model that reflects cell interactions better than existing 2D models and shows that programmed cell death (apoptosis) is crucial for calcification.
- By using porcine valvular interstitial cell spheroids, researchers found that inhibiting apoptosis reduced calcification, and the addition of antioxidants (like ascorbic acid) further decreased calcification, indicating the importance of extracellular matrix production and oxidative stress in this process.
Background: Fear of hypoglycemia in people with type 1 diabetes has a detrimental effect on glycemic control and quality of life. The association between continuous glucose monitoring (CGM) and hypoglycemia confidence and fear has not previously been assessed in the young adult population.
Methods: This was a prospective cohort study using questionnaires to assess the impact of CGM on hypoglycemia confidence (using the Hypoglycemia Confidence Scale [HCS]) and hypoglycemia fear (using the Hypoglycemia Fear Survey II [HFS]) in 40 young adults with a preexisting diagnosis of type 1 diabetes.
Background: Little is known on how greenspace redevelopment-creating or improving existing parks and trails-targeted for low-income and/or majority Black neighborhoods could amplify existing social environmental stressors, increase residents' susceptibility to displacement, and impact their sleep quality.
Objective: To examine the relationship between social environmental stressors associated with displacement and sleep quality among Black adults.
Methods: Linear regression models were employed on survey data to investigate the association between social environmental stressors, independently and combined, on sleep quality among Black adults residing in block groups targeted for greenspace redevelopment (i.
Objectives: How spinal cord stimulation (SCS) in its different modes suppresses pain is poorly understood. Mechanisms of action may reside locally in the spinal cord, but also involve a larger network including subcortical and cortical brain structures. Tonic, burst, and high-frequency modes of SCS can, in principle, entrain distinct temporal activity patterns in this network, but finally have to yield specific effects on pain suppression.
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