Publications by authors named "C Costantini"

Moving from the earlier periods in which the lungs were believed to represent sterile environments, our knowledge on the lung microbiota has dramatically increased, from the first descriptions of the microbial communities inhabiting the healthy lungs and the definition of the ecological rules that regulate its composition, to the identification of the changes that occur in pathological conditions. Despite the limitations of lung as a microbiome reservoir due to the low microbial biomass and abundance, defining its microbial composition and function in the upper and lower airways may help understanding the impact on local homeostasis and its disruption in lung diseases. In particular, the understanding of the metabolic and immune significance of microbes, their presence or lack thereof, in health and disease states could be valuable in development of novel druggable targets in disease treatments.

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  • * Recent research indicates that the gut microbiome plays a crucial role in cardiovascular health by activating immune and inflammatory responses, impacting various CVDs.
  • * This review focuses on how metabolites from gut microbiota, particularly those derived from tryptophan, interact with immune systems, potentially leading to new, microbiome-based strategies for CVD treatment.
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Recent dengue outbreaks have occurred in Ouagadougou and Bobo-Dioulasso, the two major cities of Burkina Faso. Dengue is a viral disease transmitted primarily by Aedes aegypti, a highly anthropophilic mosquito that thrives in human-transformed environments and breeds predominantly in artificial containers. In 2018, we investigated the resting and blood-feeding habits of Ae.

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  • Consumption of raw or undercooked wild boar meat is a significant risk for hepatitis E virus (HEV) infection in humans, especially due to potential contamination during slaughtering.
  • A study in Umbria, Italy, revealed that 10.8% of wild boar livers tested positive for HEV RNA, indicating a presence of infection in the region's wild boar population.
  • The research also found that HEV contamination in muscle tissue occurred in 33% of positive livers and 14% of negative livers, highlighting the need for better hygiene practices in handling wild boar carcasses to protect consumers.
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