Publications by authors named "C Coskun"
Congenital thrombotic thrombocytopenic purpura (cTTP), which is associated with mutations in the gene for a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 (ADAMTS13), is a chronic and lifelong disease. The clinical course is variable. Regularly using ADAMTS13-containing products such as fresh frozen plasma (FFP) for long-term prophylaxis is the most important treatment to prevent thrombotic microangiopathy (TMA) episodes.
View Article and Find Full Text PDFIntroduction: Optical Coherence Tomography Angiography (OCTA) is an examination that is increasingly used in neurodegenerative diseases. This study in multiple sclerosis (MS) patients; It aims to reveal the presence of vascular involvement in the retina and optic nerve and its relationship with disease-related clinical parameters with the help of OCTA.
Methods: One eye of 49 MS patients and 28 healthy controls were included in the study.
CYR61 as a Potential Apoptosis Biomarker in Osteoarthritis with Comorbidities.
J Musculoskelet Neuronal Interact
December 2024
Objective: Obesity and diabetes mellitus (DM) are major risk factors for osteoarthritis (OA), but it remains unclear how comorbidity affects apoptosis signaling in OA. This study investigated the effect of metabolic diseases on apoptosis and apoptosis-related intracellular and extracellular signaling in OA.
Methods: Excision materials of human articular cartilage from total knee arthroplasties were collected.
Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disease affecting 1% of the global population, more common in females, and this study examines the anti-inflammatory effects of INSL3, a peptide hormone predominantly found in males.
- The research involved in vivo experiments with male rats treated with varying doses of INSL3 and prednisolone, assessing joint inflammation, severity, and thermal sensitivity, revealing that INSL3 reduced inflammation but was less effective than prednisolone overall.
- In vitro tests on macrophage cells showed that higher doses of INSL3 improved cell viability and morphology, suggesting it could be a supportive treatment alongside existing therapies for RA.
Article Synopsis
- Atrial fibrillation (AF) is often triggered by atrial premature complexes (APCs) during exercise, and this study aims to understand their relationship through long-term patient follow-up.
- The research involved 1559 patients without obstructive coronary artery disease, divided into AF (+) and AF (-) groups based on the development of AF over an average follow-up of around 48 months.
- Findings indicate that older age and the presence of APCs during exercise significantly increase the risk of developing AF, with patients showing APCs having a much lower AF-free survival rate.