Publications by authors named "C Corey"
Lyme Disease Prophylaxis by Single-Dose Doxycycline in the United States, 2010-2020.
Open Forum Infect Dis
October 2024
Single-dose doxycycline after high-risk tick bites can prevent Lyme disease, which disproportionately affects children. We described single-dose doxycycline dispensings in an outpatient cohort in the United States. During 2010-2020, a total of 427 105 patients received ≥1 dispensing(s); most were aged ≥65 years.
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- The study explores how hypoxia affects blood vessel behavior in pulmonary arterial hypertension (PAH) through a genetic and epigenetic mechanism involving HIF-2α.
- HIF-2α enhances the expression of certain genes and long noncoding RNAs that contribute to increased vascular dysfunction, creating a feedback loop that further boosts HIF-2α activity.
- A specific genetic variant (rs73184087) is linked to an increased risk of PAH; interventions that either inhibit this pathway or reduce HIF-2α levels showed protective effects against the disease in animal models.
Purpose: The US Food and Drug Administration established the Sentinel System to monitor the safety of medical products. A component of this system includes parameterizable analytic tools to identify mother-infant pairs and evaluate infant outcomes to enable the routine monitoring of the utilization and safety of drugs used in pregnancy. We assessed the feasibility of using the data and tools in the Sentinel System by assessing a known association between topiramate use during pregnancy and oral clefts in the infant.
View Article and Find Full Text PDFPurpose: Develop and test a flexible, scalable tool using interrupted time series (ITS) analysis to assess the impact of Food and Drug Administration (FDA) regulatory actions on drug use.
Methods: We applied the tool in the Sentinel Distributed Database to assess the impact of FDA's 2010 drug safety communications (DSC) concerning the safety of long-acting beta2-agonists (LABA) in adult asthma patients. We evaluated changes in LABA use by measuring the initiation of LABA alone and concomitant use of LABA and asthma controller medications (ACM) after the DSCs.
Introduction: While risk factors for cigarette smoking among youth and young adults are well-documented, less is known about the correlates of initiation of other tobacco products. This study aims to provide estimates and correlates of initiation among U.S.
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