Ondansetron-related hemorrhagic posterior reversible encephalopathy syndrome (PRES) following gastric bypass.

Background: Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiographic syndrome formally recognized in 1996, which describes specific changes noted on neuroimaging thought to be related to impaired cerebral blood flow autoregulation and endothelial dysfunction. We report a case of PRES in the setting of increased ingestion of ondansetron; complicated by hemorrhagic transformation and refractory intracranial hypertension. We hypothesize an association of 5-HT3 antagonism and PRES.

Evaluation of feeding intolerance in patients with pentobarbital-induced coma.

Background: There is considerable debate regarding the appropriateness of feeding patients by the enteral route in conjunction with pentobarbital coma therapy.

Objective: To determine the incidence of feeding intolerance (FI) in patients receiving pentobarbital in conjunction with enteral nutrition (EN).

Methods: A retrospective, observational evaluation of patients (>14 y of age) who received a therapeutic pentobarbital coma in combination with EN was conducted.

Higher hemoglobin is associated with improved outcome after subarachnoid hemorrhage.

Objective: There are few data regarding anemia and transfusion after subarachnoid hemorrhage (SAH). We addressed the hypothesis that higher hemoglobin (HGB) levels are associated with less death and disability after SAH.

Design: Prospective registry with automated data retrieval.

Cardiac troponin elevation, cardiovascular morbidity, and outcome after subarachnoid hemorrhage.

Background: Cardiac troponin I (cTI) release occurs frequently after subarachnoid hemorrhage (SAH) and has been associated with a neurogenic form of myocardial injury. The prognostic significance and clinical impact of these elevations remain poorly defined.

Methods And Results: We studied 253 SAH patients who underwent serial cTI measurements for clinical or ECG signs of potential cardiac injury.

Chemical meningitis after cerebral aneurysm treatment using two second-generation aneurysm coils: report of two cases.

Objective And Importance: In the quest for effective and durable endovascular aneurysm treatment, second-generation aneurysm coils endeavor to increase the biological healing response to the implanted material. We report two cases of large cerebral aneurysms treated concurrently with both available second-generation aneurysm coils and the subsequent development of symptomatic nonbacterial meningitis.

Clinical Presentation: Two previously healthy patients underwent endovascular treatment for large (>=2 cm) cerebral aneurysms.