Publications by authors named "C Colliva"
Article Synopsis
- The study investigates the long-term psychosocial impacts of cancer treatments like cisplatin and carboplatin on pediatric patients, emphasizing the need to explore sex differences in neuropsychological outcomes.
- Using structured assessments, researchers evaluated executive functions and psychosocial factors in pediatric cancer survivors, discovering that males performed better than females in key cognitive areas.
- The results underline the importance of understanding these sex-specific cognitive differences to create tailored interventions, suggesting future research should involve larger groups and longer-term studies.
A structure-based drug design approach was focused on incorporating phenyl ring heterocyclic bioisosteres into coumarin derivative 1, previously reported as potent dual AChE-MAO B inhibitor, with the aim of improving drug-like features. Structure-activity relationships highlighted that bioisosteric rings were tolerated by hMAO B enzymatic cleft more than hAChE. Interestingly, linker homologation at the basic nitrogen enabled selectivity to switch from hAChE to hBChE.
View Article and Find Full Text PDFBackground: Pediatric cancer presents mental and physical challenges for patients and their caregivers. However, parental distress has been understudied despite its negative impact on quality of life, disability, and somatic disorders. Parents of oncopediatric patients experience high levels of suffering with their resilience tested throughout their children's illness.
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