Publications by authors named "C Collin Bone"
Introduction: Interferon-alpha (IFN-α) is a key mediator of antiviral immune responses used to treat Hepatitis-C virus (HCV) infection. Though clinically effective, IFN-α frequently induces functionally impairing mood and motivation symptoms, particularly fatigue. Unlike mood impairment, which typically emerges after weeks of treatment, fatigue tends to emerge and evolve rapidly, typically within hours of the first IFN-α injection.
View Article and Find Full Text PDFArticle Synopsis
- Western diets can cause problems like liver diseases, and people are eating less protein from animals.
- A study looked at how a low-protein diet (LPD) helps mice fight liver damage when they get infected with bacteria.
- The findings showed that LPD reduces inflammation and helps the immune system work better by changing how immune cells behave in the liver.
Background & Aims: Senescence has been reported to have differential functions in cholangiocytes and hepatic stellate cells (HSCs) during human and murine cholestatic disease, being detrimental in biliary cells and anti-fibrotic in HSCs. Cholestatic liver disease is associated with loss of intestinal barrier function and changes in the microbiome, the mechanistic cause of which is undetermined.
Methods: Intestinal samples were analysed from controls and patients with primary sclerosing cholangitis, as well as wild-type (WT) and p16-3MR transgenic mice.
Associations Between Opioid and Kratom Use in the USA: Differences by Race/Ethnicity and Sexual Orientation.
J Racial Ethn Health Disparities
August 2024
Article Synopsis
- Kratom, marketed as an opioid alternative, is federally unregulated and its effects and motivations for use vary by race/ethnicity and sexual orientation, highlighting disparities.
- A national survey indicated that 26.76% of participants used opioids in the past year, with opioid use significantly associated with both lifetime and past-year kratom use, though this association was weaker among non-Hispanic Black and Hispanic individuals.
- The study also revealed that opioid misuse and use disorder were positively correlated with kratom use, but for bisexual participants, opioid use disorder decreased the likelihood of using kratom, suggesting complex interactions between race/ethnicity, sexual orientation, and substance use.