Publications by authors named "C Colle"
Purpose: Adaptive MRgRT by 1.5 T MR-linac requires independent verification of the plan-of-the-day by the primary TPS (Monaco) (M). Here we validated a Monte Carlo-based dose-check including the magnetostatic field, SciMoCa (S).
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- Severe aortic stenosis (AS) leads to changes in the heart’s left ventricle and can affect blood flow and resistance in coronary arteries.
- A study assessed coronary blood flow and microvascular resistance in AS patients before and after transcatheter aortic valve implantation (TAVI) and found no immediate changes right after the procedure.
- Six months post-TAVI, patients showed significant improvement in hyperaemic perfusion, indicating that over time, left ventricular remodelling positively affected blood flow during increased demand.
Background: 5‑Fluoruracil (5-FU) and its oral prodrug capecitabine are mainstays in combined chemoradiotherapy regimens. They are metabolized by dihydropyrimidine dehydrogenase (DPYD). Pathogenic variants of the DPYD gene cause a reduction in DPYD activity, leading to possibly severe toxicities.
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- Stereotactic radiosurgery/radiotherapy (SRS/SRT) and systemic treatments like tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) are effective for managing brain metastases in non-small cell lung cancer (NSCLC), but the best treatment sequence is unclear.
- A retrospective analysis of 54 NSCLC patients compared outcomes between those receiving upfront SRS/SRT and those initially treated with TKI/ICI, examining overall survival (OS), intracranial progression-free survival (iPFS), and treatment-related toxicity.
- The study found no significant differences in OS and iPFS between the two treatment sequences, indicating that both approaches could be similarly effective in managing NSCLC brain metast
The early limb bud consists of mesenchymal limb progenitors derived from the lateral plate mesoderm (LPM). The LPM also gives rise to the mesodermal components of the flank and neck. However, the cells at these other levels cannot produce the variety of cell types found in the limb.
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