Publications by authors named "C Colin"
In recent decades, immunometabolism in cancers has emerged as an interesting target for treatment development. Indeed, the tumor microenvironment (TME) unique characteristics such as hypoxia and limitation of nutrients availability lead to a switch in metabolic pathways in both tumor and TME cells in order to support their adaptation and grow. Glioblastoma (GBM), the most frequent and aggressive primary brain tumor in adults, has been extensively studied in multiple aspects regarding its immune population, but research focused on immunometabolism remains limited.
View Article and Find Full Text PDFrVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination.
View Article and Find Full Text PDFPhenotypic and epigenetic heterogeneity in FGFR2-fused glial and glioneuronal tumours.
Neuropathol Appl Neurobiol
December 2024
Aims: FGFR-fused central nervous system (CNS) tumours are rare and are usually within the glioneuronal and neuronal tumours or the paediatric-type diffuse low-grade glioma spectrum. Among this spectrum, FGFR2 fusion has been documented in tumours classified by DNA-methylation profiling as polymorphous low-grade neuroepithelial tumours of the young (PLNTY), a recently described tumour type. However, FGFR2 fusions have also been reported in glioneuronal tumours, highlighting the overlapping diagnostic criteria and challenges.
View Article and Find Full Text PDFArticle Synopsis
- Blue/turquoise crystals of SrCr(PO) were synthesized through a high-temperature reaction, achieving a prismatic shape with dimensions up to 1 mm and a complex crystal structure that includes both Cr(1) and Cr(2) ions.
- The electronic configuration of these ions leads to significant Jahn-Teller effects, resulting in distinct square-pyramidal and square-planar coordination, and a layered arrangement that affects their magnetic properties.
- At low temperatures, the material exhibits interesting magnetic ordering transitions, including an antiferromagnetic structure for Cr(1) and a subsequent ordering of Cr(2), which alters the crystal's symmetry and underscores the complexity of interactions within the chromium phosphate framework.
Background: In POLA cohort, three pathological groups of CNS WHO grade 3 oligodendroglioma IDH-mutant and 1p/19q co-deleted have been described: group 1 (high mitotic count only), group 2 (microvascular proliferation MVP and no necrosis), and group 3 (MVP and necrosis).
Methods: 494 patients from the POLA cohort, with a median follow up of 96 months were included. To identify the impact of the pathological groups and contrast enhancement in group 1 on overall survival (OS) or progression free survival (PFS), survival curves were obtained (Kaplan-Meier method) and compared (log-rank test).