Publications by authors named "C Colbert"
Background: Available assays to measure pox virus neutralizing antibody titers are laborious and take up to 5 days. In addition, assays to measure T cell responses require the use of specific antigens, which may not be the same for all pox viruses. This study reports the development of robust assays for the measurement of mpox-specific neutralizing antibodies and IFN-γ-producing T-cell responses.
View Article and Find Full Text PDFIn Europe and North America, the prevalence of pulmonary nontuberculous mycobacteria (NTM) is increasing. Most pulmonary NTM infections are caused by the complex (MAC). Sadly, the treatment of pulmonary MAC is suboptimal with failure rates ranging from 37% to 58%.
View Article and Find Full Text PDFArticle Synopsis
- Cell surface signaling (CSS) in Gram-negative bacteria modulates transcription in response to external stimuli, specifically through the pseudobactin BN7/8 uptake system, which also regulates its own transcription.
- The PupB and PupR proteins form a periplasmic complex that remains inactive in the absence of iron, and recent crystal structure studies have allowed exploration of the effects of specific mutations on this complex.
- Experimental techniques like NMR and calorimetry show that while mutations (Q69K, H72D, L74A) reduce thermal stability and weaken binding interactions, they do not significantly change the overall structure of PupB’s N-terminal signaling domain.