Subjective assessment of frequency distribution histograms and consequences on reference interval accuracy for small sample sizes: A computer-simulated study.

Background: Inaccuracy in estimating reference intervals (RIs) is a problem with small sample sizes.

Objectives: This study aimed to identify the most accurate statistical methods to estimate RIs based on sample size and population distribution shape. We also studied the accuracy of sample frequency distribution histograms to retrieve the original population distribution and compared strategies based on the histogram and goodness-of-fit test.

Comparison of STA-NeoPTimal (Stago) and STA-Neoplastine CI Plus (Stago) thromboplastin reagents using a STA Satellite Max analyzer to measure prothrombin times in dogs.

Background: Different thromboplastins are available to measure prothrombin time (PT). Stago coagulation analyzers and reagents are currently used in veterinary laboratories and enable PT measurements to explore the coagulation cascade (extrinsic pathway).

Objectives: The main objective was to compare PT measurements obtained with the STA-NeoPTimal reagent with the commonly used STA-Neoplastine CI Plus reagent.

Systematic review of efficacy of nutraceuticals to alleviate clinical signs of osteoarthritis.

Background: Various treatments of osteoarthritis (OA) have been described, including use of nutraceuticals.

Objectives: To review systematically the literature about the effects of nutraceuticals on clinical signs of pain or abnormal locomotion in horses, dogs, and cats, and to discuss methodological aspects of trials and systematic reviews.

Methods: A systematic search of controlled trials evaluating the impact of nutraceuticals on OA in horses, dogs, and cats was performed, using Medline, CAB Abstracts, and Google Scholar.