Publications by authors named "C Cobelli"
Context: Defects in insulin secretion and action contribute to the progression of prediabetes to diabetes. However, the contribution of α-cell dysfunction to this process has been unclear.
Objective: Understand the relative contributions of α-cell and β-cell dysfunction to declining glucose tolerance.
Background: Cystic Fibrosis (CF) patients historically suffered from undernutrition, infection and inflammation. Insulin insufficiency-related protein catabolism further compromised health. We aimed to determine whether insulin improves protein catabolism in CF youth with abnormal glucose tolerance (AGT).
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- Genetic variation at rs10830963 has been linked to type 2 diabetes, but its specific impact on insulin and glucose regulation is not fully understood.
- This study aimed to evaluate how this genetic variant affects islet function in individuals without diabetes by testing factors like glucose and insulin levels among 294 participants.
- Results indicated that carrying one or two copies of the G-allele at rs10830963 led to higher post-meal glucose and glucagon levels, suggesting it may influence diabetes risk through alterations in α-cell function.
Article Synopsis
- * A study of 128 participants examined changes in islet function over three years, comparing those with the TT genotype (linked to diabetes) and a protective allele.
- * Results showed that individuals with the TT genotype experienced worsening glucose tolerance and problems with glucagon suppression, indicating α-cell dysfunction may develop before β-cell issues in the onset of type 2 diabetes.
Background: Strict adherence to multiple daily insulin (MDI) therapy is a cornerstone for the achievement of good glucose control in people with advanced type 2 diabetes (T2D). Here, we aim to assess glucose control in T2D subjects with poor adherence to MDI therapy.
Methods: We tuned the Padova T2D Simulator, originally describing early-stage T2D physiology, around advanced T2D people.